KCNJ16

Identifiers

KCNJ16, BIR9, KIR5.1, potassium voltage-gated channel subfamily J member 16

External IDs

MGI: 1314842 HomoloGene: 23112 GeneCards: KCNJ16

Genetically Related Diseases

Gene ontology
Molecular function	• voltage-gated ion channel activity • inward rectifier potassium channel activity • G-protein activated inward rectifier potassium channel activity
Cellular component	• integral component of membrane • voltage-gated potassium channel complex • plasma membrane • basolateral plasma membrane • integral component of plasma membrane • membrane
Biological process	• potassium ion transport • regulation of ion transmembrane transport • ion transport • potassium ion import • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3773


16517

Ensembl


ENSG00000153822


ENSMUSG00000051497

UniProt


Q9NPI9


Q9Z307

RefSeq (mRNA)

NM_001270422 NM_001291622 NM_001291623 NM_001291624 NM_001291625
NM_018658 NM_170741 NM_170742


NM_001252207 NM_001252208 NM_001252209 NM_001252210 NM_010604

RefSeq (protein)

NP_001257351.1 NP_001278551.1 NP_001278552.1 NP_001278553.1 NP_001278554.1
NP_061128.2 NP_733937.2 NP_733938.2


NP_001239136.1 NP_001239137.1 NP_001239138.1 NP_001239139.1 NP_034734.3

Location (UCSC)

Chr 17: 70.05 – 70.14 Mb

Chr 11: 110.97 – 111.03 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.^[4]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir5.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.^[4]

References

Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pearson WL, Dourado M, Schreiber M, et al. (1999). "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. (Lond.). 514 ( Pt 3) (3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMC 2269105. PMID 9882736.
Liu Y, McKenna E, Figueroa DJ, et al. (2000). "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. doi:10.1159/000015662. PMID 11060447.
Derst C, Karschin C, Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146.
Pessia M, Imbrici P, D'Adamo MC, et al. (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. (Lond.). 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMC 2278540. PMID 11306656.
Tanemoto M, Fujita A, Higashi K, Kurachi Y (2002). "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron. 34 (3): 387–97. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170.
Konstas AA, Korbmacher C, Tucker SJ (2003). "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. doi:10.1152/ajpcell.00479.2002. PMID 12456399.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Casamassima M, D'Adamo MC, Pessia M, Tucker SJ (2003). "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. doi:10.1074/jbc.M306596200. PMID 12923169.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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KCNJ16

See also

References

Further reading