TRPV5

TRPV5
Identifiers
Aliases	TRPV5, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5
External IDs	MGI: 2429764 HomoloGene: 10520 GeneCards: TRPV5
Targeted by Drug
econazole, miconazole[1]
Gene ontology Molecular function • ion channel activity • protein binding • calmodulin binding • calcium channel activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • apical plasma membrane • membrane Biological process • ion transport • protein tetramerization • calcium ion transport • transport • transmembrane transport • regulation of urine volume • calcium ion homeostasis • calcium ion transmembrane transport • calcium ion import into cell Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56302	194352
Ensembl	n/a	ENSMUSG00000036899
UniProt	Q9NQA5	P69744
RefSeq (mRNA)	NM_019841	NM_001007572
RefSeq (protein)	NP_062815.3	NP_001007573.1
Location (UCSC)	Chr 7: 142.91 – 142.93 Mb	Chr 6: 41.65 – 41.68 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.^[4][5][6]

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺.^[7] Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consequentual hyperparathyroidism, and bone loss.^[8]

Function

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.^[9]

Interactions

TRPV5 has been shown to interact with S100A10.^[10]

See also

• TRPV

References

1. "Drugs that physically interact with Transient receptor potential cation channel subfamily V member 5 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem. Biophys. Res. Commun. 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439.
5. Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, García-Nieto V, Claverie-Martín F, Bindels RJ (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics. 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469.
6. Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
7. Hoenderop JG, Nilius B, Bindels RJ (2002). "Molecular mechanism of active Ca2+ reabsorption in the distal nephron". Annu. Rev. Physiol. 64: 529–49. doi:10.1146/annurev.physiol.64.081501.155921. PMID 11826278.
8. Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van der Kemp AW, Mérillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ (2003). "Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5". J. Clin. Invest. 112 (12): 1906–14. doi:10.1172/JCI19826. PMC 297001. PMID 14679186.
9. "Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5".
10. van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ (Apr 2003). "Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex". EMBO J. 22 (7): 1478–87. doi:10.1093/emboj/cdg162. PMC 152906. PMID 12660155.

Further reading

• Vennekens R, Droogmans G, Nilius B (2001). "Functional properties of the epithelial Ca2+ channel, ECaC". Gen. Physiol. Biophys. 20 (3): 239–53. PMID 11765215.
• Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium. 33 (5-6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698.
• Nijenhuis T, Hoenderop JG, Bindels RJ (2005). "TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate". Pflugers Arch. 451 (1): 181–92. doi:10.1007/s00424-005-1430-6. PMID 16044309.
• Mensenkamp AR, Hoenderop JG, Bindels RJ (2007). "TRPV5, the gateway to Ca2+ homeostasis". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 207–20. doi:10.1007/978-3-540-34891-7_12. ISBN 978-3-540-34889-4. PMID 17217059.
• Schoeber JP, Hoenderop JG, Bindels RJ (2007). "Concerted action of associated proteins in the regulation of TRPV5 and TRPV6". Biochem. Soc. Trans. 35 (Pt 1): 115–9. doi:10.1042/BST0350115. PMID 17233615.

External links

• TRPV5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.