KCNK6

KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	MGI: 1891291 HomoloGene: 31266 GeneCards: KCNK6
Gene ontology Molecular function • potassium ion leak channel activity • inward rectifier potassium channel activity • voltage-gated ion channel activity • potassium channel activity Cellular component • integral component of membrane • voltage-gated potassium channel complex • plasma membrane • membrane Biological process • regulation of resting membrane potential • potassium ion transport • regulation of ion transmembrane transport • stabilization of membrane potential • cardiac conduction • ion transport • negative regulation of systemic arterial blood pressure • potassium ion transmembrane transport • regulation of systemic arterial blood pressure • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9424	52150
Ensembl	ENSG00000099337	ENSMUSG00000046410
UniProt	Q9Y257	n/a
RefSeq (mRNA)	NM_004823	NM_001033525
RefSeq (protein)	NP_004814.1 NP_004814.1	n/a
Location (UCSC)	Chr 19: 38.32 – 38.33 Mb	Chr 7: 29.22 – 29.23 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.^[3][4][5][6]

This gene encodes K_2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.^[6]

See also

• Tandem pore domain potassium channel

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
4. Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428.
5. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
6. "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
• Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management". Gastrointestinal radiology. 1 (2): 167–71. PMID 1088718.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
• Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit". FEBS Lett. 450 (3): 191–6. doi:10.1016/S0014-5793(99)00495-0. PMID 10359073.
• Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel". J. Biol. Chem. 275 (37): 28722–30. doi:10.1074/jbc.M003755200. PMID 10887187.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4". J. Neurosci. Res. 75 (1): 25–31. doi:10.1002/jnr.10839. PMID 14689445.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• KCNK6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.