SYT3

SYT3
Identifiers
Aliases	SYT3, SytIII, synaptotagmin 3
External IDs	MGI: 99665 HomoloGene: 9617 GeneCards: SYT3
Gene ontology Molecular function • clathrin binding • calcium ion binding • metal ion binding • calcium-dependent phospholipid binding • syntaxin binding Cellular component • integral component of membrane • endosome • transport vesicle membrane • exocytic vesicle • membrane • cytoplasmic vesicle • presynapse • plasma membrane • cell Biological process • positive regulation of dendrite extension • cell differentiation • calcium ion regulated exocytosis • calcium ion-regulated exocytosis of neurotransmitter • regulation of calcium ion-dependent exocytosis • vesicle fusion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84258	20981
Ensembl	ENSG00000213023	ENSMUSG00000030731
UniProt	Q9BQG1	O35681
RefSeq (mRNA)	NM_001160328 NM_001160329 NM_032298	NM_001114116 NM_016663
RefSeq (protein)	NP_001153800.1 NP_001153801.1 NP_115674.1 NP_001153800.1 NP_001153801.1 NP_115674.1	NP_001107588.1 NP_057872.3
Location (UCSC)	Chr 19: 50.62 – 50.67 Mb	Chr 7: 44.38 – 44.4 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. PMID 7749232.
4. "Entrez Gene: SYT3 synaptotagmin III".

Further reading

• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
• Fukuda M, Kanno E, Mikoshiba K (October 1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". The Journal of Biological Chemistry. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
• Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry. 275 (9): 6328–36. doi:10.1074/jbc.275.9.6328. PMID 10692432.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.