VAMP1

VAMP1
Identifiers
Aliases	VAMP1, SPAX1, SYB1, VAMP-1, vesicle associated membrane protein 1
External IDs	MGI: 1313276 HomoloGene: 40678 GeneCards: VAMP1
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein binding Cellular component • terminal bouton • synaptic vesicle membrane • synapse • integral component of membrane • mitochondrion • tertiary granule membrane • azurophil granule membrane • cell junction • integral component of plasma membrane • neuron projection • membrane • cell surface • specific granule membrane • mitochondrial outer membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • cytosol • SNARE complex Biological process • SNARE complex assembly • vesicle fusion • vesicle-mediated transport • exocytosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6843	22317
Ensembl	ENSG00000139190	ENSMUSG00000030337
UniProt	P23763	Q62442
RefSeq (mRNA)	NM_001297438 NM_014231 NM_016830 NM_199245	NM_001080557 NM_009496
RefSeq (protein)	NP_001284367.1 NP_055046.1 NP_058439.1 NP_954740.1	NP_001074026.1 NP_033522.1
Location (UCSC)	Chr 12: 6.46 – 6.47 Mb	Chr 6: 125.22 – 125.25 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.^[3][4]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:429.0px; top:646px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:142.0px; top:421px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:62px; height:0px; overflow:hidden; position:relative; left:693.0px; top:561px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:545.0px; top:144px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:352.0px; top:192px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:234.0px; top:388px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:446.0px; top:45px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:50px; height:0px; overflow:hidden; position:relative; left:248.0px; top:593px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:815px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:249.29411764705878px; top:671.949579831933px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:380.0px; top:464px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:433.0px; top:532px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:776px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:795px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:369.0px; top:505px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:146px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:42px; height:0px; overflow:hidden; position:relative; left:518.0px; top:551px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:167px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:255.0px; top:125px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:775px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:429.0px; top:626px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:207px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:186px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:255.0px; top:236px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:618.4705882352949px; top:730.210084033613px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:816px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:45px; height:0px; overflow:hidden; position:relative; left:190.0px; top:596px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:246.0px; top:820px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:53.25px; height:0px; overflow:hidden; position:relative; left:296.75px; top:556.25px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:187px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:619.3025210084037px; top:666.521008403362px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:46px; height:0px; overflow:hidden; position:relative; left:697.7310924369746px; top:643.36974789916px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:614.5084033613451px; top:610.184873949579px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:142.0px; top:441px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:780px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:796px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:206px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:443.0px; top:413px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:39px; height:0px; overflow:hidden; position:relative; left:698.7058823529412px; top:698.865546218488px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:85.0px; top:388px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:760px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:614.6050420168065px; top:497.857142857143px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:43px; height:0px; overflow:hidden; position:relative; left:305.0px; top:125px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:166px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:352.0px; top:172px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:43px; height:0px; overflow:hidden; position:relative; left:305.0px; top:236px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:494.0px; top:590px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:816.4537815126054px; top:497.857142857143px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:493.0px; top:253px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:800px; background:transparent; border-top:3px blue solid"></div>]]

[[

]]

|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Archer BT III, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem. 265 (28): 17267–73. PMID 1976629.
4. "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".

Further reading

• Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
• Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317. ( Pt 3): 945–54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387.
• Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
• Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333. ( Pt 2): 247–51. doi:10.1042/bj3330247. PMC 1219579. PMID 9657962.
• Isenmann S, Khew-Goodall Y, Gamble J, et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.". Mol. Biol. Cell. 9 (7): 1649–60. doi:10.1091/mbc.9.7.1649. PMC 25402. PMID 9658161.
• Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
• Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
• Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.