Stromelysin 1

Stromelysin 1
Identifiers
EC number 3.4.24.17
CAS number 79955-99-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Stromelysin 1 (EC 3.4.24.17, matrix metalloproteinase 3, proteoglycanase, collagenase activating protein, procollagenase activator, transin, MMP-3, neutral proteoglycanase, stromelysin, collagen-activating protein) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Preferential cleavage where P1', P2' and P3' are hydrophobic residues

This extracellular endopeptidase is present in vertebrate tissues.

References

  1. Chin, J.R.; Murphy, G.; Werb, Z. (1985). "Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates". J. Biol. Chem. 260: 12367–12376. PMID 2995374.
  2. Okada, Y.; Nagase, H.; Harris, E.D. Jr. (1986). "A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization". J. Biol. Chem. 261: 14245–14255. PMID 3095317.
  3. Docherty, A.J.P.; Murphy, G. (1990). "The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins". Ann. Rheum. Dis. 49: 469–479. PMID 2197998.
  4. Emonard, H.; Grimaud, J.A. (1990). "Matrix metalloproteinase. A review". Cell. Mol. Biol. 36: 131–153. PMID 2165861.
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