Hydrocodone/ibuprofen

Hydrocodone/ibuprofen
Combination of
Hydrocodone Opioid analgesic
Ibuprofen Non-steroidal anti-inflammatory drug
Clinical data
Trade names Ibudone, Reprexain, Vicoprofen
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a601006
License data
Pregnancy
category
  • US: C (Risk not ruled out)
Dependence
liability
Moderate
Routes of
administration
Oral
ATC code M01AE51 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability >80%
Metabolism for hydrocodone: hepatic, CYP3A4; for ibuprofen: hepatic, CYP2C9
Biological half-life for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs)
Excretion for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged)
Identifiers
CAS Number 615580-69-3 YesY
PubChem (SID) 7849213
KEGG D02152 YesY
  (verify)

The drug combination hydrocodone/ibuprofen (INNs, trade name Vicoprofen) is an analgesic medication used in short-term therapy to relieve severe pain.[1] Hydrocodone is used in form of the bitartrate. This combination avoids some of the liver toxicity which may occur with hydrocodone/paracetamol combinations such as Vicodin, but still presents significant dangers in hydrocodone overdose, namely respiratory depression.

Generic hydrocodone/ibuprofen 7.5/200 mg

See also

References

  1. Drugs.com: Vicoprofen


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