5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid

Names
IUPAC name 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
Identifiers
CAS Number	131123-76-7
3D model (Jmol)	Interactive image
ChemSpider	1714
IUPHAR/BPS	2361
PubChem	1779
InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N InChI=1/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) Key: BGKFPRIGXAVYNX-UHFFFAOYAD
SMILES C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
Properties
Chemical formula	C10H5Cl2NO3
Molar mass	258.05 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

5,7-Dichlorokynurenic acid (DCKA) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.^[1]

See also

• 7-Chlorokynurenic acid
• Kynurenic acid

References

1. McNamara D, Smith EC, Calligaro DO, O'Malley PJ, McQuaid LA, Dingledine R. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neuroscience Letters. 1990 Nov 27;120(1):17-20. PMID 2149877