Angiotensin II receptor type 2

AGTR2

Identifiers

Aliases

AGTR2, AT2, ATGR2, MRX88, Angiotensin II receptor type 2

External IDs

MGI: 87966 HomoloGene: 20172 GeneCards: AGTR2

Genetically Related Diseases

cystic fibrosis^[1]

Targeted by Drug

EMA401^[2]

Gene ontology
Molecular function	• signal transducer activity • receptor antagonist activity • peptide hormone binding • G-protein coupled receptor activity • transcription factor binding • protein binding • angiotensin type II receptor activity
Cellular component	• integral component of membrane • membrane • perinuclear region of cytoplasm • plasma membrane • integral component of plasma membrane • extracellular region
Biological process	• regulation of metanephros size • regulation of transcription factor import into nucleus • positive regulation of metanephric glomerulus development • intracellular signal transduction • kidney morphogenesis • regulation of apoptotic process • positive regulation of cytokine secretion • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of nitric-oxide synthase activity • signal transduction • dopamine biosynthetic process • positive regulation of nitric oxide biosynthetic process • negative regulation of norepinephrine secretion • cellular sodium ion homeostasis • renin-angiotensin regulation of aldosterone production • cellular response to dexamethasone stimulus • positive regulation of vasodilation • brain development • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • brain renin-angiotensin system • regulation of blood pressure • kidney development • negative regulation of icosanoid secretion • positive regulation of extrinsic apoptotic signaling pathway • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • aldosterone secretion • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • negative regulation of blood vessel endothelial cell migration • negative regulation of neurotrophin TRK receptor signaling pathway • response to organonitrogen compound • cerebellar cortex development • regulation of vasodilation • negative regulation of fibroblast proliferation • blood vessel remodeling • cell growth involved in cardiac muscle cell development • negative regulation of heart rate • negative regulation of cell growth • positive regulation of phosphoprotein phosphatase activity • exploration behavior • inflammatory response • positive regulation of renal sodium excretion • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • nitric oxide mediated signal transduction • angiotensin-activated signaling pathway • extracellular negative regulation of signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


186


11609

Ensembl


ENSG00000180772


ENSMUSG00000068122

UniProt


P50052


P35374

RefSeq (mRNA)


NM_000686


NM_007429

RefSeq (protein)


NP_000677.2


NP_031455.1

Location (UCSC)

Chr X: 116.17 – 116.17 Mb

Chr X: 21.48 – 21.49 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Angiotensin II receptor type 2, also known as the AT₂ receptor is a protein that in humans is encoded by the AGTR2 gene.^[5]

Function

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT₁ and AT₂. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.^[5]

Stimulation of AT₂ by the selective agonist CGP 42112A increases mucosal nitric oxide production.^[6]

Model organisms

*Agtr2* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Eye Histopathology	Normal
All tests and analysis from^[7]^[8]

Model organisms have been used in the study of AGTR2 function. A conditional knockout mouse line, called Agtr2^{tm1a(EUCOMM)Wtsi}^[9]^[10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[11]^[12]^[13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[7]^[14] Twenty one tests were carried out on mutant mice, but no significant abnormalities were observed.^[7]

Interactions

Angiotensin II receptor type 2 has been shown to interact with MTUS1.^[15] nope

References

↑ "Diseases that are genetically associated with AGTR2 view/edit references on wikidata".
↑ "Drugs that physically interact with Type-2 angiotensin II receptor view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: AGTR2 angiotensin II receptor, type 2".
↑ Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L (March 2003). "The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa". BMC Pharmacol. 3: 2. doi:10.1186/1471-2210-3-2. PMC 153509. PMID 12689346.
1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
↑ "International Knockout Mouse Consortium".
↑ "Mouse Genome Informatics".
↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
↑ Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". J. Biol. Chem. 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.

External links

"Angiotensin Receptors: AT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

de Gasparo M, Catt KJ, Inagami T, "", et al. (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Parmacol Rev. 52 (3): 415–472. PMID 10977869.
D'Amore A, Black MJ, Thomas WG (2005). "The angiotensin II type 2 receptor causes constituative growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy". Hypertension. 46 (6): 1347–1354. doi:10.1161/01.HYP.0000193504.51489.cf. PMID 16286564.

Regitz-Zagrosek V, Neuss M, Warnecke C, et al. (1997). "Subtype 2 and atypical angiotensin receptors in the human heart". Basic Res. Cardiol. 91 Suppl 2: 73–7. doi:10.1007/bf00795366. PMID 8957548.
Berry C, Touyz R, Dominiczak AF, et al. (2002). "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide". Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400.
Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor". Biochem. Biophys. Res. Commun. 183 (2): 910–6. doi:10.1016/0006-291X(92)90570-B. PMID 1550596.
Hein L, Barsh GS, Pratt RE, et al. (1995). "Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice". Nature. 377 (6551): 744–7. doi:10.1038/377744a0. PMID 7477266.
Ichiki T, Labosky PA, Shiota C, et al. (1995). "Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor". Nature. 377 (6551): 748–50. doi:10.1038/377748a0. PMID 7477267.
Lazard D, Briend-Sutren MM, Villageois P, et al. (1995). "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues". Recept. Channels. 2 (4): 271–80. PMID 7719706.
Martin MM, Elton TS (1995). "The sequence and genomic organization of the human type 2 angiotensin II receptor". Biochem. Biophys. Res. Commun. 209 (2): 554–62. doi:10.1006/bbrc.1995.1537. PMID 7733925.
Chassagne C, Beatty BG, Meloche S (1995). "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization". Genomics. 25 (2): 601–3. doi:10.1016/0888-7543(95)80072-T. PMID 7790004.
Koike G, Horiuchi M, Yamada T, et al. (1994). "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung". Biochem. Biophys. Res. Commun. 203 (3): 1842–50. doi:10.1006/bbrc.1994.2402. PMID 7945336.
Martin MM, Su B, Elton TS (1995). "Molecular cloning of the human angiotensin II type 2 receptor cDNA". Biochem. Biophys. Res. Commun. 205 (1): 645–51. doi:10.1006/bbrc.1994.2714. PMID 7999093.
Tsuzuki S, Ichiki T, Nakakubo H, et al. (1994). "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor". Biochem. Biophys. Res. Commun. 200 (3): 1449–54. doi:10.1006/bbrc.1994.1613. PMID 8185599.
Servant G, Boulay G, Bossé R, et al. (1993). "Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium". Mol. Pharmacol. 43 (5): 677–83. PMID 8502225.
Yamada T, Horiuchi M, Dzau VJ (1996). "Angiotensin II type 2 receptor mediates programmed cell death". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 156–60. doi:10.1073/pnas.93.1.156. PMC 40197. PMID 8552595.
Zhang J, Pratt RE (1996). "The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus". J. Biol. Chem. 271 (25): 15026–33. doi:10.1074/jbc.271.25.15026. PMID 8663053.
Katsuya T, Horiuchi M, Minami S, et al. (1997). "Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome". Mol. Cell. Endocrinol. 127 (2): 221–8. doi:10.1016/S0303-7207(97)04011-2. PMID 9099917.
Akishita M, Ito M, Lehtonen JY, et al. (1999). "Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth". J. Clin. Invest. 103 (1): 63–71. doi:10.1172/JCI5182. PMC 407869. PMID 9884335.
Lehtonen JY, Daviet L, Nahmias C, et al. (1999). "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis". Mol. Endocrinol. 13 (7): 1051–60. doi:10.1210/me.13.7.1051. PMID 10406457.
Knowle D, Ahmed S, Pulakat L (2000). "Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family". Regul. Pept. 87 (1–3): 73–82. doi:10.1016/S0167-0115(99)00111-1. PMID 10710290.
Hansen JL, Servant G, Baranski TJ, et al. (2000). "Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation". Circ. Res. 87 (9): 753–9. doi:10.1161/01.res.87.9.753. PMID 11055978.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Adhesion	ADGRG (1 2 3 4 5 6 7)

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Protein and peptide receptor modulators

Adiponectin

AdipoR₁	Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon (–)-Arctigenin Arctiin Gramine Matairesinol Antagonists: Peptide: ADP-400

AdipoR₂	Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol Antagonists: Peptide: ADP-400

Angiotensin

Agonists: Angiotensin II
Angiotensin III
Angiotensin IV
Saralasin

Antagonists: Abitesartan
Azilsartan
Azilsartan medoxomil
Candesartan
Elisartan
Embusartan
Eprosartan
EXP-3174
Fimasartan
Forasartan
Irbesartan
Losartan
Milfasartan
Olmesartan
Olmesartan medoxomil
PD123319
Pomisartan
Pratosartan
Ripisartan
Saprisartan
Sparsentan
Tasosartan
Telmisartan
Valsartan
Zolasartan

Renin inhibitors: Aliskiren
Ciprokiren
Ditekiren
Enalkiren
Pepstatin
Remikiren
Terlakiren
Zankiren

Propeptides: Angiotensinogen
Angiotensin I

Bradykinin

Agonists: Bradykinin
Kallidin

Antagonists: FR-173657
Icatibant
LF22-0542

CGRP

Agonists: Amylin
CGRP
Pramlintide

Antagonists: BI 44370 TA
BMS-927711
CGRP (8-37)
MK-3207
Olcegepant
Rimegepant
SB-268262
Telcagepant
Ubrogepant

Antibodies: ALD403
Eptinezumab
Erenumab
Fremanezumab

Cholecystokinin

CCK_A	Agonists: Cholecystokinin Antagonists: Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide

CCK_B	Agonists: Cholecystokinin CCK-4 Gastrin Pentagastrin (CCK-5) Antagonists: CI-988 (PD-134308) Itriglumide L-365,360 Netazepide Proglumide Spiroglumide

Unsorted	Antagonists: Nastorazepide

CRH

CRF₁	Agonists: Cortagine Corticorelin Corticotropin releasing hormone Sauvagine Stressin I Urocortin Antagonists: Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin LWH-234 NBI-27914 Pexacerfont R-121919 TS-041 Verucerfont

CRF₂	Agonists: Corticorelin Corticotropin releasing hormone Sauvagine Urocortin Antagonists: Astressin-B

Cytokine

See here instead.

Endothelin

Agonists: Endothelin 1
Endothelin 2
Endothelin 3
IRL-1620

Antagonists: A-192621
ACT-132577
Ambrisentan
Atrasentan
Avosentan
Bosentan
BQ-123
BQ-788
Clazosentan
Darusentan
Edonentan
Enrasentan
Fandosentan
Feloprentan
Macitentan
Nebentan
Sitaxentan
Sparsentan
Tezosentan
Zibotentan

Galanin

GAL₁	Agonists: Galanin Galanin (1-15) Galanin-like peptide Galmic Galnon Antagonists: C7 Dithiepine-1,1,4,4-tetroxide Galantide (M15) M32 M35 M40 SCH-202596

GAL₂	Agonists: Galanin Galanin (1-15) Galanin (2-11) Galanin-like peptide Galmic Galnon J18 Antagonists: C7 Galantide (M15) M32 M35 M40 M871

GAL₃	Agonists: Galanin Galanin (1-15) Galmic Galnon Antagonists: C7 Galantide (M15) GalR3ant HT-2157 M32 M35 M40 SNAP-37889 SNAP-398299

Ghrelin/GHS

Agonists: Peptide: Alexamorelin
Cortistatin-14
Examorelin (hexarelin)
Ghrelin
GHRP-1
GHRP-3
GHRP-4
GHRP-5
GHRP-6
Ipamorelin
Lenomorelin
Pralmorelin (GHRP-2)
Relamorelin
Tabimorelin
Ulimorelin; Non-peptide: Adenosine
Anamorelin
Capromorelin
CP-464709
Ibutamoren (MK-677)
L-692,585
Macimorelin
SM-130686; Unsorted: LY-426410
LY-444711

Antagonists: A-778193
Cortistatin-8
(D-Lys³)-GHRP-6
JMV2959
YIL-781

Binding proteins: Growth hormone-binding protein

Agonists: Bovine somatotropin
Efpegsomatropin
Growth hormone
Human placental lactogen
Somagrebove
Somapacitan
Somatosalm
Somatotropin
Somatropin pegol
Somatrem
Sometribove
Somatrogon (MOD-4023; hGH-CTP)
Somavaratan
Somavubove
Somidobove

Antagonists: G120K-hGH
Pegvisomant

GHRH

Agonists: Peptide: CJC-1295
Dumorelin
GHRH
Modified GRF (1-29)
Rismorelin
Sermorelin
Somatorelin
Tesamorelin

Antagonists: MZ-5-156

GLP

GLP-1	Agonists: Albiglutide Dulaglutide Efpeglenatide Exenatide GLP-1 Langlenatide Liraglutide Lixisenatide Oxyntomodulin Semaglutide Taspoglutide

GLP-2	Agonists: Elsiglutide GLP-2 Teduglutide

Others	Propeptides: Preproglucagon Proglucagon

Glucagon

Agonists: Glucagon
Oxyntomodulin

Antagonists: Adomeglivant
L-168,049
LGD-6972

Propeptides: Preproglucagon
Proglucagon

GnRH

Antagonists: Peptide: Abarelix
Acyline
Cetrorelix
Degarelix
Detirelix
Ganirelix
Iturelix
Ozarelix
Prazarelix
Ramorelix
Teverelix (antarelix); Non-peptide: ASP-1707
Elagolix
KLH-2109
Relugolix
Sufugolix

Gonadotropin

LH/CG	Agonists: Choriogonadotropin alfa Human chorionic gonadotropin Luteinizing hormone Lutropin alfa Menotropin (human menopausal gonadotropin)

FSH	Agonists: Corifollitropin alfa Follicle-stimulating hormone Follitropin alfa Follitropin beta Follitropin epsilon Menotropin (human menopausal gonadotropin) Urofollitropin Varfollitropin alfa NAMs: ADX-61623

Growth factor

See here instead.

Insulin

Antagonists: BMS-754807
S661
S961

Kinase inhibitors: Linsitinib

Kisspeptin

Agonists: Kisspeptin
Kisspeptin-10

Antagonists: Kisspeptin-234

Leptin

Agonists: Leptin
Metreleptin

MCH

MCH₁	Agonists: Melanin concentrating hormone Antagonists: ATC-0065 ATC-0175 GW-803430 NGD-4715 SNAP-7941 SNAP-94847

MCH₂	Agonists: Melanin concentrating hormone

Melanocortin

See here instead.

Neuropeptide FF

Agonists: Neuropeptide AF
Neuropeptide FF
Neuropeptide SF (RFRP-1)
Neuropeptide VF (RFRP-3)

Antagonists: BIBP-3226
RF9

Neuropeptide S

Agonists: Neuropeptide S

Antagonists: ML-154
SHA-68

Neuropeptide Y

Y₁	Agonists: Neuropeptide Y Peptide YY Antagonists: BIBO-3304 BIBP-3226 BVD-10 GR-231118 PD-160170

Y₂	Agonists: 2-Thiouridine 5'-triphosphate Neuropeptide Y Neuropeptide Y (13-36) Peptide YY Peptide YY (3-36) Antagonists: BIIE-0246 JNJ-5207787 SF-11

Y₄	Agonists: GR-231118 Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists: UR-AK49

Y₅	Agonists: BWX-46 Neuropeptide Y Peptide YY Antagonists: CGP-71683 FMS-586 L-152,804 Lu AA-33810 MK-0557 NTNCB Velneperit (S-2367)

Neurotensin

NTS₁	Agonists: Neurotensin Neuromedin N Antagonists: Meclinertant SR-142948

NTS₂	Agonists: Neurotensin Antagonists: Levocabastine SR-142948

Opioid

See here instead.

Orexin

OX₁	Agonists: Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant SB-334867 SB-408124 SB-649868 Suvorexant TCS-1102

OX₂	Agonists: Orexin (A, B) SB-668875 Antagonists: ACT-335827 ACT-462206 Almorexant EMPA Filorexant JNJ-10397049 MIN-202 (JNJ-42847922) Lemborexant MK-1064 SB-649868 Suvorexant TCS-1102 TCS-OX2-29

Unsorted	Antagonists: Seltorexant

Oxytocin

See here instead.

Prolactin

Antagonists: Δ1–9-G129R-hPRL
Δ1–14-G129R-hPRL
G120K-hGH
G129R-hPRL

PTH

Agonists: Abaloparatide
Parathyroid hormone
Parathyroid hormone-related protein (PTHrP)
Semparatide
Teriparatide

Relaxin

Somatostatin

Agonists: BIM-23052
CH-275
Cortistatin-14
Depreotide
Ilatreotide
L-803,087
L-817,818
Lanreotide
NNC 26-9100
Octreotide
Pasireotide
Pentetreotide
RC-160
Seglitide
Somatostatin (GHIH)
Somatostatin (1-28)
SRIF-14
SRIF-28
TT-232
Vapreotide

Antagonists: BIM-23056
Cyclosomatostatin
CYN-154806
Satoreotide

Tachykinin

NK₁	Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant

NK₂	Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant

NK₃	Agonists: Neurokinin B Antagonists: Fezolinetant Osanetant Talnetant

TRH

Agonists: Azetirelin
Fertirelin
Montirelin
Orotirelin
Posatirelin
Protirelin
Rovatirelin
Taltirelin
TRH (TRF)

TSH

Agonists: Thyrotropin alfa
TSH (thyrotropin)

Vasopressin

See here instead.

VIP/PACAP

VIPR₁	Agonists: Peptide: Bay 55-9837 LBT-3393 PACAP VIP

VIPR₂	Agonists: Peptide: LBT-3627 PACAP VIP

PAC₁	Agonists: PACAP PACAP (1-27) PACAP (1-38) Antagonists: PACAP (6-38)

Unsorted	PHI PHM PHV

Others

Endogenous: Adrenomedullin
Apelin
Bombesin
Calcitonin
Carnosine
CART
CLIP
DSIP
Enteroglucagon
Formyl peptide
GALP
GIP
GRP
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin)
Kininogens
Motilin
Natriuretic peptides (ANP, BNP, CNP, urodilatin)
Nesfatin-1
Neuromedin B
Neuromedin N
Neuromedin S
Neuromedin U
Obestatin
Osteocalcin
Resistin
Secretin
Thymopoietin
Thymosins
Thymulin
Urotensin-II
VGF

Exogenous: Lifitegrast (LFA-1 antagonist)

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Angiotensin II receptor type 2

Function

Model organisms

Interactions

See also

References

External links

Further reading