Biogenesis of lysosome-related organelles complex 3

BLOC-3 or biogenesis of lysosome-related organelles complex 3 is a ubiquitously expressed multisubunit protein complex.^[1][2][3]

Interactions

biogenesis of lysosome-related organelles complex 3 has been shown to interact with Rab9A.^[4]

Complex Components

The identified protein subunits of BLOC-1 include:

• HPS1,
• HPS4

References

1. Chiang PW, Oiso N, Gautam R, Suzuki T, Swank RT, Spritz RA (May 2003). "The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are components of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles". J. Biol. Chem. 278 (22): 20332–20337. doi:10.1074/jbc.m300090200. PMID 12663659.
2. Martina JA, Moriyama K, Bonifacino JS (August 2003). "BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4". J. Biol. Chem. 278 (31): 29376–29384. doi:10.1074/jbc.m301294200. PMID 12756248.
3. Nazarian R, Falcón-Pérez JM, Dell'Angelica EC (July 2003). "Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4". Proc. Natl. Acad. Sci. USA. 100 (15): 8770–8775. doi:10.1073/pnas.1532040100. PMC 166388. PMID 12847290.
4. Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS (March 2010). "Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9". J. Biol. Chem. 285 (10): 7794–7804. doi:10.1074/jbc.M109.069088. PMC 2844223. PMID 20048159.