PSNCBAM-1

PSNCBAM-1

Identifiers
IUPAC name 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea
CAS Number	877202-74-9
PubChem (CID)	11560249
Chemical and physical data
Formula	C22H21ClN4O
Molar mass	392.89 g·mol^−1
3D model (Jmol)	Interactive image
SMILES Clc1ccc(NC(=O)Nc2cccc(c2)c3cccc(n3)N4CCCC4)cc1
InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28) Key:HDAYFSFWIPRJSO-UHFFFAOYSA-N

PSNCBAM-1 is a negative allosteric modulator of the cannabinoid CB₁ receptor.^[1][2]

See also

• GAT100
• Org 27569
• ZCZ-011

References

1. German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y (September 2014). "Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)". Journal of Medicinal Chemistry. 57 (18): 7758–7769. doi:10.1021/jm501042u. PMC 4175001. PMID 25162172.
2. Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P (November 2007). "PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats". British Journal of Pharmacology. 152 (5): 805–814. doi:10.1038/sj.bjp.0707347. PMC 2190018. PMID 17592509.