Fenestrel

Fenestrel

Clinical data
ATC code	None
Identifiers
IUPAC name 5-Ethyl-6-methyl-4-phenylcyclohex-3-ene-1-carboxylic acid
Synonyms	Demethoxyhoggolic acid; NSC-86465; 2-methyl-3-ethyl-4-phenyl-δ^4-cyclohexenecarboxylic acid
CAS Number	7698-97-7
PubChem (CID)	24371
ChemSpider	22786
Chemical and physical data
Formula	C16H20O2
Molar mass	244.3288 g/mol
3D model (Jmol)	Interactive image
SMILES CCC1C(C(CC=C1C2=CC=CC=C2)C(=O)O)C
InChI InChI=1S/C16H20O2/c1-3-13-11(2)14(16(17)18)9-10-15(13)12-7-5-4-6-8-12/h4-8,10-11,13-14H,3,9H2,1-2H3,(H,17,18) Key:CLMFEXDZPBGYQQ-UHFFFAOYSA-N

Fenestrel (INN, USAN) (developmental code name ORF-3858) is a synthetic, non-steroidal estrogen that was developed as a postcoital contraceptive in the 1960s but was never marketed.^[1][2][3] Synthesized by Ortho Pharmaceutical in 1961 and studied extensively, it was coined the "morning-after-pill" or "postcoital antifertility agent".^[4] Fenestrel is a seco analogue of doisynolic acid, and a member of the cyclohexenecarboxylic acid series of estrogens.^[5][6]

See also

• Carbestrol
• Methallenestril
• Doisynoestrol
• Bisdehydrodoisynolic acid
• Anordrin

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 517–. ISBN 978-1-4757-2085-3.
2. Revaz C, Goldenberg B, Achtari H (1971). "[Critical study of new contraceptive methods]". Schweiz Med Wochenschr (in French). 101 (3): 92–6. PMID 5544232.
3. Kunjappu MJ (2011). "Pioneering studies of the "morning-after" pill". Yale J Biol Med. 84 (2): 109–11. PMC 3117403. PMID 21698041.
4. Stanley R. Glasser; David W. Bullock (6 December 2012). Cellular and Molecular Aspects of Implantation. Springer Science & Business Media. pp. 478–. ISBN 978-1-4613-3180-3.
5. Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 672. ISBN 978-0-471-02065-3.
6. Acta europaea fertilitatis. Piccin Medical Books. 1969.