Flutemazepam

Flutemazepam

Clinical data
Pregnancy category	X
Routes of administration	Oral
ATC code	none
Legal status
Legal status	US: Schedule IV Schedule IV (International)
Identifiers
IUPAC name 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
CAS Number	52391-89-6
PubChem (CID)	40344
ChemSpider	36859
UNII	J8U5694BCW
ChEMBL	CHEMBL291770
ECHA InfoCard	100.052.612
Chemical and physical data
Formula	C16H12ClFN2O2
Molar mass	318.730
3D model (Jmol)	Interactive image
SMILES FC1=CC=CC=C1C2=NC(C(N(C)C3=C2C=C(C=C3)Cl)=O)O
InChI InChI=1S/C16H12ClFN2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 Key:RMFYWNFETXNTIQ-UHFFFAOYSA-N
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Flutemazepam^[1] was developed at a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. Is a drug which is a 3-hydroxy benzodiazepine derivative and an analogue of temazepam that has hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. It is most closely related in structure to temazepam and is indicated for the treatment of severe insomnia.^[2] Flutemazepam has properties similar to temazepam, and it has been found to be very effective for the treatment of severe states of anxiety, panic attacks, and severe insomnia.^[3]

See also

• Benzodiazepine

References

1. GB Patent 1431282 - BENZODIAZEPINE COMPOUNDS FOR THEREPEUTICAL USE
2. "flutemazepam". psychotropics.dk. Retrieved 11 February 2009.
3. Ian K.M. Morton, Judith M. Hall. Concise Dictionary of Pharmacological agents. Springer, 1999. ISBN 0-7514-0499-3, ISBN 978-0-7514-0499-9