List of estrogens available in the United States

This is a complete list of estrogens and formulations that are approved by the FDA and available in the United States. Estrogens are used as hormonal contraceptives, in hormone replacement therapy, and in the treatment of gynecological disorders.

Estrogen-only

Oral/sublingual pills

• Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg

• Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg
• Estradiol (Estradiol, Gynodiol, Innofem) – 0.5 mg, 1 mg, 2 mg
• Estradiol acetate (Femtrace) – 0.45 mg, 0.9 mg, 1.8 mg
• Estropipate (Estropipate, Ogen .625, Ogen 1.25, Ogen 2.5, Ogen 5, Ortho-Est) – 0.75 mg, 1.5 mg, 3 mg, 6 mg
• Synthetic conjugated estrogens (Cenestin, Enjuvia)^[1] – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg

Atypical (nitrogen mustard alkylating antineoplastic):

• Estramustine phosphate sodium (Emcyt) – 140 mg

Discontinued:

• Chlorotrianisene (TACE)^[2]
• Dienestrol (Synestrol)^[2]
• Diethylstilbestrol (DES, Diethylstilbestrol, Stilbestrol, Stilbetin)
• Ethinyl estradiol (Estinyl, Feminone, Lynoral)
• Fosfestrol (Stilphostrol)
• Hexestrol (Estra Plex)^[2]
• Methallenestril (Vallestril)^[2]
• Quinestrol (Estrovis)

Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe.^[3]

Transdermal patches

• Estradiol (Alora, Climara, Esclim, Estraderm, Estradiol, Fempatch, Menostar, Minivelle, Vivelle, Vivelle-Dot) – 14 μg/24 hours, 25 μg/24 hours, 37.5 μg/24 hours, 50 μg/24 hours, 60 μg/24 hours, 75 μg/24 hours, 100 μg/24 hours

Transdermal gels

• Estradiol (Divigel, Elestrin, Estrogel) – 0.06% (0.87 g/activation, 1.25 g/activation), 0.1% (0.25 g/packet, 0.5 g/packet, 1 g/packet)

Transdermal sprays

• Estradiol (Evamist) – 1.53 mg/spray

Topical emulsions

• Estradiol hemihydrate (Estrasorb) – 0.25%

Vaginal tablets

• Estradiol (Estradiol, Vagifem) – 10 μg (25 μg discontinued)

Vaginal creams

• Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%)
• Estradiol (Estrace) – 0.01%
• Synthetic conjugated estrogens (Synthetic Conjugated Estrogens A) – 0.625 mg/g (0.0625%)

Discontinued:

• Dienestrol (Dienestrol, Dinestrol, DV, Estraguard)
• Estropipate (Ogen) – 1.5 mg/g (0.15%)

Vaginal inserts

• Estradiol (Estring) – 7.5 μg/24 hours
• Estradiol acetate (Femring) – 50 μg/24 hours, 100 μg/24 hours

Vaginal suppositories

Discontinued:

• Dienestrol (DV)
• Diethylstilbestrol (Diethylstilbestrol, Stilbestrol)

Intramuscular injection

• Conjugated estrogens (Premarin) – 25 mg/vial
• Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued)
• Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL

Discontinued:

• Diethylstilbestrol (Stilbestrol)
• Estrone (Estrogenic Substance, Estrone, Natural Estrogenic Substance-Estrone, Theelin)
• Fosfestrol (Stilphostrol)
• Polyestradiol phosphate (Estradurin)

Combined with progestins

For contraception

⇾ See here instead.

For menopausal symptoms

Oral pills

• Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg
• Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg
• Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg
• Ethinyl estradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg

Discontinued:

• Estradiol and norgestimate (Prefest) – 1 mg / 90 μg

Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone, is under development.^[4]

Transdermal patches

• Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
• Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours

Combined with androgens

Oral pills

Discontinued:

• Dienestrol and methyltestosterone (Estan, Lucidon)^[2]

Injection

Discontinued:

• Estradiol cypionate and testosterone cypionate (Depo-Testadiol)
• Estradiol valerate and testosterone enanthate (Ditate-DS)

Combined with other drugs

Oral pills

• Conjugated estrogens and bazedoxifene acetate (Duavee) – 20 mg / 0.45 mg

Discontinued:

• Esterified estrogens and chlordiazepoxide (Menrium 5-2, Menrium 5-4, Menrium 10-4)
• Conjugated estrogens and meprobamate (Milprem-200, Milprem-400, PMB 200, PMB 400)

See also

• List of progestogens available in the United States
• List of androgens/anabolic steroids available in the United States
• List of steroidal estrogens
• Estrogen ester
• Oral contraceptive formulations
• Estradiol-containing oral contraceptive

Notes

1. Mary C. Brucker; Tekoa L. King (8 September 2015). Pharmacology for Women’s Health. Jones & Bartlett Learning. pp. 640–. ISBN 978-1-284-10811-8. Two types of synthetic estrogen mixtures exist that are primarily used for menopausal hormone therapy: synthetic conjugated estrogens and esterified estrogens. The synthetic conjugated estrogen mixtures are derived from yam or soy plants and contain several types of estrogen. Both synthetic conjugated estrogen products available in the United States (Cenestin with 9 estrogens and Enjuvia with 10 estrogens) contain the primary estrogens in CEE, but the products are not considered equivalent to Premarin.
2. William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 981,1286,1833,2214,2266. ISBN 978-0-8155-1856-3.
3. Joseph S. Sanfilippo (January 1998). Primary Care in Obstetrics and Gynecology: A Handbook for Clinicians. Springer Science & Business Media. pp. 227–. ISBN 978-0-387-94739-6.
4. Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B (2015). "Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy". Menopause. 22 (12): 1308–16. doi:10.1097/GME.0000000000000467. PMC 4666011. PMID 25944519.

References

• "Drugs@FDA: FDA Approved Drug Products" (HTML). United States Food and Drug Administration. Retrieved 16 November 2016.
• "DailyMed" (HTML). National Institutes of Health: United States National Library of Medicine. Retrieved 12 October 2016.

External links

• For Women: Menopause—Medicines to Help You – U.S. Food and Drug Administration